Tumor-Specific Diagnostic Marker for Transmissible Facial Tumors of Tasmanian Devils: Immunohistochemistry Studies
C Tovar, D Obendorf, EP Murchison, AT Papenfuss, A Kreiss, GM Woods
Veterinary Pathology | SAGE PUBLICATIONS INC | Published : 2011
Devil facial tumor disease (DFTD) is a transmissible neoplasm that is threatening the survival of the Tasmanian devil. Genetic analyses have indicated that the disease is a peripheral nerve sheath neoplasm of Schwann cell origin. DFTD cells express genes characteristic of myelinating Schwann cells, and periaxin, a Schwann cell protein, has been proposed as a marker for the disease. Diagnosis of DFTD is currently based on histopathology, cytogenetics, and clinical appearance of the disease in affected animals. As devils are susceptible to a variety of neoplastic processes, a specific diagnostic test is required to differentiate DFTD from cancers of similar morphological appearance. This study..View full abstract
The author(s) disclosed receipt of the following financial support for the research and/or authorship of this article: a Dr Eric Guiler Tasmanian Devil Research Grant and support from the Turner Foundation.