Journal article

An epigenetic silencing pathway controlling T helper 2 cell lineage commitment

Rhys S Allan, Elina Zueva, Florence Cammas, Heidi A Schreiber, Vanessa Masson, Gabrielle T Belz, Daniele Roche, Christele Maison, Jean-Pierre Quivy, Genevieve Almouzni, Sebastian Amigorena



During immune responses, naive CD4+ T cells differentiate into several T helper (TH) cell subsets under the control of lineage-specifying genes. These subsets (TH1, TH2 and TH17 cells and regulatory T cells) secrete distinct cytokines and are involved in protection against different types of infection. Epigenetic mechanisms are involved in the regulation of these developmental programs, and correlations have been drawn between the levels of particular epigenetic marks and the activity or silencing of specifying genes during differentiation. Nevertheless, the functional relevance of the epigenetic pathways involved in TH cell subset differentiation and commitment is still unclear. Here we exp..

View full abstract


Awarded by ANR

Awarded by European Commission Network of Excellence EpiGeneSys

Awarded by Australian National Health and Medical Research Council-INSERM

Funding Acknowledgements

We are grateful to the late R. Losson for the generation of the HP1 alpha-deficient mice. We acknowledge the members of the Department of Pathology and the Nikon Imaging Centre at the Institut Curie-CNRS. We thank T. Jenuwein for providing the SUV39H1-deficient mice and the members of INSERM U932 and CNRS UMR218 for discussions and suggestions. This work was supported by ANR-09-BLAN-0257 ('ECens'), ANR 2010 1326 03 and HEALTH-F4-2010-257082 (from the European Commission Network of Excellence EpiGeneSys) to G. A., ANR 2009 BLAN-0021 EPIGO to F. C., and ANR 2010 BLAN-1326 01 and a grant from the Ligue National de Lutte contre le Cancer (Ligue equipe labelisee 2011-2013) to S. A. and E.Z. E.Z. and H. A. S. were funded by Fellowship of the Institut Curie (Paris), and R. S. A. was funded by an Australian National Health and Medical Research Council-INSERM fellowship (461286).