Journal article
An epigenetic silencing pathway controlling T helper 2 cell lineage commitment
RS Allan, E Zueva, F Cammas, HA Schreiber, V Masson, GT Belz, D Roche, C Maison, JP Quivy, G Almouzni, S Amigorena
Nature | NATURE PUBLISHING GROUP | Published : 2012
DOI: 10.1038/nature11173
Abstract
During immune responses, naive CD4 + T cells differentiate into several T helper (T H) cell subsets under the control of lineage-specifying genes. These subsets (T H1, T H2 and T H17 cells and regulatory T cells) secrete distinct cytokines and are involved in protection against different types of infection. Epigenetic mechanisms are involved in the regulation of these developmental programs, and correlations have been drawn between the levels of particular epigenetic marks and the activity or silencing of specifying genes during differentiation. Nevertheless, the functional relevance of the epigenetic pathways involved in T H cell subset differentiation and commitment is still unclear. Here ..
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Funding Acknowledgements
We are grateful to the late R. Losson for the generation of the HP1 alpha-deficient mice. We acknowledge the members of the Department of Pathology and the Nikon Imaging Centre at the Institut Curie-CNRS. We thank T. Jenuwein for providing the SUV39H1-deficient mice and the members of INSERM U932 and CNRS UMR218 for discussions and suggestions. This work was supported by ANR-09-BLAN-0257 ('ECens'), ANR 2010 1326 03 and HEALTH-F4-2010-257082 (from the European Commission Network of Excellence EpiGeneSys) to G. A., ANR 2009 BLAN-0021 EPIGO to F. C., and ANR 2010 BLAN-1326 01 and a grant from the Ligue National de Lutte contre le Cancer (Ligue equipe labelisee 2011-2013) to S. A. and E.Z. E.Z. and H. A. S. were funded by Fellowship of the Institut Curie (Paris), and R. S. A. was funded by an Australian National Health and Medical Research Council-INSERM fellowship (461286).