Journal article

Engineering Enzyme-Cleavable Hybrid Click Capsules with a pH-Sheddable Coating for Intracellular Degradation

Sylvia T Gunawan, Kang Liang, Georgina K Such, Angus PR Johnston, Melissa KM Leung, Jiwei Cui, Frank Caruso

SMALL | WILEY-V C H VERLAG GMBH | Published : 2014


The engineering of layer-by-layer (LbL) hybrid click capsules that are responsive to biological stimuli is reported. The capsules comprise a pH-sheddable, non cross-linked outer coating that protects enzyme-cleavable inner layers. Upon cellular uptake, the outer coating is released and the capsules are enzymatically degraded. In vitro cell degradation results in rapid capsule degradation (10 min) upon cellular internalization.