Journal article

GINGIVAL HYPERPLASIA IN RENAL-ALLOGRAFT RECIPIENTS RECEIVING CYCLOSPORINE-A AND CALCIUM-ANTAGONISTS

GN KING, R FULLINFAW, TJ HIGGINS, RG WALKER, DMA FRANCIS, D WIESENFELD

Journal Of Clinical Periodontology | MUNKSGAARD INT PUBL LTD | Published : 1993

Abstract

Although it is established that the immunosuppressant cyclosporin-A (CsA) and calcium antagonists [Nifedipine (Nif) and Diltiazem (Dz)] can independently induce gingival enlargement, little has been documented on the significance of the salivary CsA levels and the combined effect of CsA and a calcium antagonist upon gingival tissues. In the present cross-sectional investigation, clinical periodontal parameters and the pharmacologic profiles of CsA, Nif, and Dz were determined for 66 renal transplant recipients. Subjects were divided into the following groups: Group (Gp) 1: CsA [n = 18]; Gp 2: CsA + Nif [n = 15]; Gp 3: CsA + Dz [n = 12] and a negative Control Gp 4: azathioprine [n = 21]. A gi..

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