Journal article

Deep brain stimulation for treatment-resistant depression: Efficacy, safety and mechanisms of action

Rodney J Anderson, Mark A Frye, Osama A Abulseoud, Kendall H Lee, Jane A McGillivray, Michael Berk, Susannah J Tye

Neuroscience & Biobehavioral Reviews | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2012

Abstract

Deep brain stimulation (DBS), a neuromodulation therapy that has been used successfully in the treatment of symptoms associated with movement disorders, has recently undergone clinical trials for individuals suffering from treatment-resistant depression (TRD). Although the small patient numbers and open label study design limit our ability to identify optimum targets and make definitive conclusions about treatment efficacy, a review of the published research demonstrates significant reductions in depressive symptomatology and high rates of remission in a severely treatment-resistant patient group. Despite these encouraging results, an incomplete understanding of the mechanisms of action unde..

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