Effect and Reporting Bias of RhoA/ROCK-Blockade Intervention on Locomotor Recovery After Spinal Cord Injury A Systematic Review and Meta-analysis
Ralf Watzlawick, Emily S Sena, Ulrich Dirnagl, Benedikt Brommer, Marcel A Kopp, Malcolm R Macleod, David W Howells, Jan M Schwab
JAMA Neurology | AMER MEDICAL ASSOC | Published : 2014
IMPORTANCE: Blockade of small GTPase-RhoA signaling pathway is considered a candidate translational strategy to improve functional outcome after spinal cord injury (SCI) in humans. Pooling preclinical evidence by orthodox meta-analysis is confounded by missing data (publication bias). OBJECTIVE: To conduct a systematic review and meta-analysis of RhoA/Rho-associated coiled-coil containing protein kinase (ROCK) blocking approaches to (1) analyze the impact of bias that may lead to inflated effect sizes and (2) determine the normalized effect size of functional locomotor recovery after experimental thoracic SCI. EVIDENCE REVIEW: We conducted a systematic search of PubMed, EMBASE, and Web of Sc..View full abstract
Awarded by Studienstiftung des deutschen Volkes
Awarded by Wings for Life Spinal Cord Research Foundation
Awarded by National Centre for the Replacement
Mr Watzlawick's work is awarded by the Studienstiftung des deutschen Volkes (grant 186392). The Charite Department of Neurology and Experimental Neurology (Watzlawick, Dirnagl, Brommer, Kopp, Schwab) is an associated member of the European Multicenter Study about Spinal Cord Injury. Dr Macleod's work is supported by the UK MRC Trials Methodology Hub. Dr Schwab receives funding from the Else-Kroner Fresenius Foundation and the Wings for Life Spinal Cord Research Foundation (grant 60-2012). No other disclosures were reported.