Journal article

The relationship between the initiation of antimicrobial therapy and the incidence of stroke in infective endocarditis: An analysis from the ICE Prospective Cohort Study (ICE-PCS)

Stuart A Dickerman, Elias Abrutyn, Bruno Barsic, Emilio Bouza, Enrico Cecchi, Asuncion Moreno, Thanh Doco-Lecompte, Damon P Eisen, Claudio Q Fortes, Vance G Fowler, Stamatios Lerakis, Jose M Miro, Paul Pappas, Gail E Peterson, Ethan Rubinstein, Daniel J Sexton, Fredy Suter, Pilar Tornos, Dominique W Verhagen, Christopher H Cabell

American Heart Journal | MOSBY-ELSEVIER | Published : 2007


BACKGROUND: Embolic events to the central nervous system are a major cause of morbidity and mortality in patients with infective endocarditis (IE). The appropriate role of valvular surgery in reducing such embolic events is unclear. The purpose of this study was to determine the relationship between the initiation of antimicrobial therapy and the temporal incidence of stroke in patients with IE and to determine if this time course differs from that shown for embolic events in previous studies. METHODS: Prospective incidence cohort study involving 61 tertiary referral centers in 28 countries. Case report forms were analyzed from 1437 consecutive patients with left-sided endocarditis admitted ..

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