Journal article
Triple Negative Breast Cancers Have a Reduced Expression of DNA Repair Genes
E Ribeiro, M Ganzinelli, D Andreis, R Bertoni, R Giardini, SB Fox, M Broggini, A Bottini, V Zanoni, L Bazzola, C Foroni, D Generali, G Damia
Plos One | Published : 2013
Abstract
DNA repair is a key determinant in the cellular response to therapy and tumor repair status could play an important role in tailoring patient therapy. Our goal was to evaluate the mRNA of 13 genes involved in different DNA repair pathways (base excision, nucleotide excision, homologous recombination, and Fanconi anemia) in paraffin embedded samples of triple negative breast cancer (TNBC) compared to luminal A breast cancer (LABC). Most of the genes involved in nucleotide excision repair and Fanconi Anemia pathways, and CHK1 gene were significantly less expressed in TNBC than in LABC. PARP1 levels were higher in TNBC than in LABC. In univariate analysis high level of FANCA correlated with an ..
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Funding Acknowledgements
The work was supported by the Italian Association for Cancer Research (AIRC), Associazione Ricerca in Campo Oncologico (ARCO) and the Victorian Breast Cancer Research Consortium of Australia. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.