Plasmodium falciparum: Growth response to potassium channel blocking compounds
Karena L Waller, Kami Kim, Thomas V McDonald
Experimental Parasitology | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2008
Potassium channels are essential for cell survival and regulate the cell membrane potential and electrochemical gradient. During its lifecycle, Plasmodium falciparum parasites must rapidly adapt to dramatically variant ionic conditions within the mosquito mid-gut, the hepatocyte and red blood cell (RBC) cytosols, and the human circulatory system. To probe the participation of K(+) channels in parasite viability, growth response assays were performed in which asexual stage P. falciparum parasites were cultured in the presence of various Ca(2+)-activated K(+) channel blocking compounds. These data describe the novel anti-malarial effects of bicuculline methiodide and tubocurarine chloride and ..View full abstract
Awarded by USAMRMC
We thank Ji-Mee Hwang for technical assistance during the initial stages of this investigation. KLW is supported by an Australian NHMRC Howard Florey Centenary Research Fellowship. This research was funded by the USAMRMC grant # DAMD17-02-1-0290.