Journal article

Runx2 and MYC collaborate in lymphoma development by suppressing apoptotic and growth arrest pathways in vivo

K Blyth, F Vaillant, L Hanlon, N Mackay, M Bell, A Jenkins, JC Neil, ER Cameron

Cancer Research | AMER ASSOC CANCER RESEARCH | Published : 2006

Abstract

Members of the Runx and MYC families have been implicated as collaborating oncogenes. The mechanism of this potent collaboration is elucidated in this study of Runx2/MYC mice. As shown previously, ectopic expression of Runx2 in the thymus leads to a preneoplastic state defined by an accumulation of cells with an immature phenotype and a low proliferative rate. We now show that c-MYC overexpression is sufficient to rescue proliferation and to release the differentiation block imposed by Runx2. Analysis of Runx2-expressing lymphomas reveals a consistently low rate of apoptosis, in contrast to lymphomas of MYC mice which are often highly apoptotic. The low apoptosis phenotype is dominant in Run..

View full abstract