Journal article

A novel Plasmodium falciparum ring stage protein, REX, is located in Maurer's clefts

PL Hawthorne, KR Trenholme, TS Skinner-Adams, T Spielmann, K Fischer, MWA Dixon, MR Ortega, KL Anderson, DJ Kemp, DL Gardiner

Molecular and Biochemical Parasitology | ELSEVIER SCIENCE BV | Published : 2004

Abstract

The asexual stages of the malaria parasite Plasmodium falciparum develop inside erythrocytes of the human host. Erythrocytes are highly specialized cells lacking organelles and trafficking machinery. The parasite must therefore establish its own transport system to export proteins and waste and import nutrients. A number of parasite-derived structures, implicated in trafficking, appear in the infected red blood cell at the late ring stage. We have identified a novel gene transcribed in ring stage parasites coding for a protein designated the ring exported protein, REX. REX is located in a red cell modification known as the Maurer's clefts, which are parasite induced structures implicated in ..

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University of Melbourne Researchers