Journal article

Stress hyperlactataemia: present understanding and controversy

Mercedes Garcia-Alvarez, Paul Marik, Rinaldo Bellomo

The Lancet Diabetes & Endocrinology | ELSEVIER SCIENCE INC | Published : 2014


An increased blood lactate concentration is common during physiological (exercise) and pathophysiological stress (stress hyperlactataemia). In disease states, there is overwhelming evidence that stress hyperlactataemia is a strong independent predictor of mortality. However, the source, biochemistry, and physiology of exercise-induced and disease-associated stress hyperlactataemia are controversial. The dominant paradigm suggests that an increased lactate concentration is secondary to anaerobic glycolysis induced by tissue hypoperfusion, hypoxia, or both. However, in the past two decades, much evidence has shown that stress hyperlactataemia is actually due to increased aerobic lactate produc..

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University of Melbourne Researchers