Highly Pathological Influenza A Virus Infection Is Associated with Augmented Expression of PD-1 by Functionally Compromised Virus-Specific CD8( ) T Cells
John A Rutigliano, Shalini Sharma, Melissa Y Morris, Thomas H Oguin, Jennifer L McClaren, Peter C Doherty, Paul G Thomas
JOURNAL OF VIROLOGY | AMER SOC MICROBIOLOGY | Published : 2014
One question that continues to challenge influenza A research is why some strains of virus are so devastating compared to their more mild counterparts. We approached this question from an immunological perspective, investigating the CD8(+) T cell response in a mouse model system comparing high- and low-pathological influenza virus infections. Our findings reveal that the early (day 0 to 5) viral titer was not the determining factor in the outcome of disease. Instead, increased numbers of antigen-specific CD8(+) T cells and elevated effector function on a per-cell basis were found in the low-pathological infection and correlated with reduced illness and later-time-point (day 6 to 10) viral ti..View full abstract
Awarded by NIH
Awarded by NIH/NIAID St. Jude Center of Excellence for Influenza Research and Surveillance
Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
This work was supported by NIH grants AI065097 (P.G.T) and RO170251 (P.C.D.) and the NIH/NIAID St. Jude Center of Excellence for Influenza Research and Surveillance (HHSN266200700005C) and American Lebanese Syrian Associated Charities at St. Jude Children's Research Hospital.