Highly Pathological Influenza A Virus Infection Is Associated with Augmented Expression of PD-1 by Functionally Compromised Virus-Specific CD8( ) T Cells
John A Rutigliano, Shalini Sharma, Melissa Y Morris, Thomas H Oguin, Jennifer L McClaren, Peter C Doherty, Paul G Thomas
JOURNAL OF VIROLOGY | AMER SOC MICROBIOLOGY | Published : 2014
One question that continues to challenge influenza A research is why some strains of virus are so devastating compared to their more mild counterparts. We approached this question from an immunological perspective, investigating the CD8(+) T cell response in a mouse model system comparing high- and low-pathological influenza virus infections. Our findings reveal that the early (day 0 to 5) viral titer was not the determining factor in the outcome of disease. Instead, increased numbers of antigen-specific CD8(+) T cells and elevated effector function on a per-cell basis were found in the low-pathological infection and correlated with reduced illness and later-time-point (day 6 to 10) viral ti..View full abstract
Awarded by NIH
Awarded by NIH/NIAID St. Jude Center of Excellence for Influenza Research and Surveillance
This work was supported by NIH grants AI065097 (P.G.T) and RO170251 (P.C.D.) and the NIH/NIAID St. Jude Center of Excellence for Influenza Research and Surveillance (HHSN266200700005C) and American Lebanese Syrian Associated Charities at St. Jude Children's Research Hospital.