Differential Host Response, Rather Than Early Viral Replication Efficiency, Correlates with Pathogenicity Caused by Influenza Viruses
Peter S Askovich, Catherine J Sanders, Carrie M Rosenberger, Alan H Diercks, Pradyot Dash, Garnet Navarro, Peter Vogel, Peter C Doherty, Paul G Thomas, Alan Aderem
PLoS One | PUBLIC LIBRARY SCIENCE | Published : 2013
Influenza viruses exhibit large, strain-dependent differences in pathogenicity in mammalian hosts. Although the characteristics of severe disease, including uncontrolled viral replication, infection of the lower airway, and highly inflammatory cytokine responses have been extensively documented, the specific virulence mechanisms that distinguish highly pathogenic strains remain elusive. In this study, we focused on the early events in influenza infection, measuring the growth rate of three strains of varying pathogenicity in the mouse airway epithelium and simultaneously examining the global host transcriptional response over the first 24 hours. Although all strains replicated equally rapidl..View full abstract
Awarded by NIAID
Awarded by NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
This work was supported by NIAID's Systems Influenza contract (HHSN272200800058C). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.