Journal article

Monocyte chemotactic protein-1 secreted by primary breast tumors stimulates migration of mesenchymal stem cells

RM Dwyer, SM Potter-Beirne, KA Harrington, AJ Lowery, E Hennessy, JM Murphy, FP Barry, T O'Brien, MJ Kerin

Clinical Cancer Research | AMER ASSOC CANCER RESEARCH | Published : 2007

Abstract

PURPOSE: Major barriers to effective adenovirus-based gene therapy include induction of an immune response and tumor-specific targeting of vectors. The use of mesenchymal stem cells (MSC) as systemic delivery vehicles for therapeutic genes has been proposed as a result of their combined ability to home in on the tumor site and evade the host immune response. This study is aimed at investigating factors mediating homing of human MSCs to breast cancer primary cultures and cell lines in vitro and in vivo. EXPERIMENTAL DESIGN: Fluorescently labeled MSCs were given to mice bearing breast cancer xenografts, and tumor tissue was harvested to detect MSC engraftment. MSC migration in response to prim..

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University of Melbourne Researchers