Journal article

A BAFF antagonist suppresses experimental autoimmune encephalomyelitis by targeting cell-mediated and humoral immune responses

Nicholas D Huntington, Ryo Tomioka, Chelsea Clavarino, Anne M Chow, David Linares, Paula Mana, Jamie Rossjohn, Teresa G Cachero, Fang Qian, Susan L Kalled, Claude CA Bernard, Hugh H Reid

International Immunology | OXFORD UNIV PRESS | Published : 2006

Abstract

BAFF [B cell-activating factor of the tumour necrosis factor (TNF) family] and APRIL (a proliferation-inducing ligand) are two TNF family members with shared receptors. While, physiological roles for APRIL are not fully understood, BAFF is critical for B cell homeostasis and also acts as a co-stimulator of T cells. Using a B and T cell-mediated mouse model of multiple sclerosis (MS), myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE), we observed that a BAFF/APRIL antagonist (soluble BCMA-Fc) inhibited central nervous system inflammation and demyelination such that it suppressed the onset and progression of clinical symptoms of EAE. In addition ..

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