Antineutrophil Cytoplasmic Antibody-Associated Vasculitides: Could Geographic Patterns Be Explained by Ambient Ultraviolet Radiation?
Paul A Gatenby, Robyn M Lucas, Ola Engelsen, Anne-Louise Ponsonby, Mark Clements
Arthritis & Rheumatology | WILEY-BLACKWELL | Published : 2009
OBJECTIVE: This ecological study describes and quantifies the association between ambient ultraviolet (UV) radiation levels, including daily winter vitamin D effective UV radiation levels and the incidence of the 3 antineutrophil cytoplasmic antibody-associated vasculitides (AAVs): Wegener's granulomatosis (WG), microscopic polyangiitis (MPA), and Churg-Strauss syndrome (CSS). Latitudinal variation in occurrence of the AAVs, especially WG, has been previously reported. For other autoimmune diseases such as multiple sclerosis and type 1 diabetes mellitus, inverse associations with latitude are hypothesized to indicate a causative role for low UV radiation exposure, possibly acting via vitamin..View full abstract
Awarded by European Commission via the European Commission-Integrated Project INTARESE
Dr. Lucas's work was supported by a Multiple Sclerosis Research Australia Fellowship and the Royal Australasian College of Physicians Cottrell Fellowship. Dr. Engelsen's work was supported by the European Commission via the European Commission-Integrated Project INTARESE (018385-2).