Journal article

Efficacy of sweet solutions for analgesia in infants between 1 and 12 months of age: a systematic review

Denise Harrison, Bonnie Stevens, Mariana Bueno, Janet Yamada, Thomasin Adams-Webber, Joseph Beyene, Arne Ohlsson

Archives of Disease in Childhood | BMJ PUBLISHING GROUP | Published : 2010


OBJECTIVE: To compare the efficacy of oral sweet solutions to water or no treatment in infants aged 1-12 months during immunisation. METHODS: Randomised controlled trials (RCTs) were retrieved through internet searches or manual searches of reference lists. Search terms included newborn, infant, pain, sucrose and alternative names for sweet solutions. Summary estimates with 95% CIs were calculated and included relative risk (RR), risk difference (RD) and number needed to treat to benefit (NNTB) for dichotomous outcomes, and weighted mean differences (WMD) for continuous outcomes. Where pooling of results was not possible, a narrative summary of study results is presented. RESULTS: Of the 695..

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University of Melbourne Researchers


Awarded by The Pain in Child Health Strategic Training Initiative

Awarded by Canadian Institutes of Health Research (CIHR)

Funding Acknowledgements

The first author, Denise Harrison was supported by The Pain in Child Health Strategic Training Initiative (STP53885) and CIHR Team Grant in Children's Pain (CTP-79854 and MOP-86605) while undertaking this review. Canadian Institutes of Health Research (CIHR) Knowledge Synthesis Grant Funding (reference number: KRS91774) financially supported this review.