The NLRP3 inflammasome in health and disease: the good, the bad and the ugly
P Menu, JE Vince
Clinical & Experimental Immunology | WILEY | Published : 2011
While interleukin (IL)-1β plays an important role in combating the invading pathogen as part of the innate immune response, its dysregulation is responsible for a number of autoinflammatory disorders. Large IL-1β activating platforms, known as inflammasomes, can assemble in response to the detection of endogenous host and pathogen-associated danger molecules. Formation of these protein complexes results in the autocatalysis and activation of caspase-1, which processes precursor IL-1β into its secreted biologically active form. Inflammasome and IL-1β activity is required to efficiently control viral, bacterial and fungal pathogen infections. Conversely, excess IL-1β activity contributes to hu..View full abstract
James E. Vince is funded by an Australian NHMRC C. J. Martin Fellowship. This work was supported by the Swiss National Science Foundation through an MD-PhD grant to Philippe Menu. Thanks to Holly Anderton and James Rickard for their help with the manuscript. This review is dedicated to the memory of Professor Jurg Tschopp.