IRF-3 partners Bax in a viral-induced dance macarbre
James E Vince, Jurg Tschopp
EMBO JOURNAL | NATURE PUBLISHING GROUP | Published : 2010
In this issue of The EMBO Journal, Chattopadhyay et al (2010) describe a surprising new mechanism for how viral dsRNA detection by the RIG-I/MAVS signalling complex can initiate apoptosis. Independent of its transcriptional function, a pool of interferon regulatory factor (IRF)-3 activated downstream of MAVS can bind to and activate cytosolic Bax, resulting in Bax translocation to the mitochondria and initiation of the intrinsic apoptotic pathway. © 2010 European Molecular Biology Organization.
JEV is supported by a Human Frontiers Science Program Fellowship. We apologize to authors whose research was unable to be cited due to space constrictions.