Journal article

SIRT1 Activates MAO-A in the Brain to Mediate Anxiety and Exploratory Drive

Sergiy Libert, Kelli Pointer, Eric L Bell, Abhirup Das, Dena E Cohen, John M Asara, Karen Kapur, Sven Bergmann, Martin Preisig, Takeshi Otowa, Kenneth S Kendler, Xiangning Chen, John M Hettema, Edwin J van den Oord, Justin P Rubio, Leonard Guarente

Cell | CELL PRESS | Published : 2011

Grants

Awarded by Leukemia and Lymphoma Society


Awarded by Swiss National Science Foundation


Awarded by National Center for Research Resources


Awarded by NATIONAL CENTER FOR RESEARCH RESOURCES


Awarded by NATIONAL INSTITUTE OF MENTAL HEALTH


Funding Acknowledgements

We would like to acknowledge Vincent Mooser, Federica Tozzi, Kijuong Song, James Ellis, Enrique Castelao, and Carol Prescott for their contribution to the provision, analysis, and interpretation of human genetic data; and Xuemei Yang for help with mass spectrometry. This work was supported by the fellowship from Leukemia and Lymphoma Society (5089-09) to S. L. and grants from the NIH and a gift from the Glenn Foundation for Medical Research to L. G. The PsyCoLaus study was supported by grants from the Swiss National Science Foundation (#3200B0-105993, #3200B0-118308, #33CSC0-122661) and from GlaxoSmithKline. S. B. was supported by the Swiss National Science Foundation (#31003A_130691), the Swiss Institute of Bioinformatics, and the European Framework Project 6. We are grateful to Mid-Atlantic Twin Registry (MATR) for the ascertainment of VATSPSUD subjects for the replication study. The MATR was supported by grant UL1RR031990 from the National Center for Research Resources. J.R. works for GlaxoSmithKline. L. G. consults for Sirtris (GSK company).