Journal article

CD4( ) CD25( ) regulatory T cells suppress CD4( ) T-cell function and inhibit the development of Plasmodium berghei-specific TH1 responses involved in cerebral malaria pathogenesis

Catherine Q Nie, Nicholas J Bernard, Louis Schofield, Diana S Hansen

Infection and Immunity | AMER SOC MICROBIOLOGY | Published : 2007

Abstract

The infection of mice with Plasmodium berghei ANKA constitutes the best available mouse model for human Plasmodium falciparum-mediated cerebral malaria, a devastating neurological syndrome that kills nearly 2.5 million people every year. Experimental data suggest that cerebral disease results from the sequestration of parasitized erythrocytes within brain blood vessels, which is exacerbated by host proinflammatory responses mediated by cytokines and effector cells including T lymphocytes. Here, T cell responses to P. berghei ANKA were analyzed in cerebral malaria-resistant and -susceptible mouse strains. CD4+ T-cell proliferation and interleukin-2 (IL-2) production in response to parasite-sp..

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University of Melbourne Researchers