Journal article

17 beta-hydroxysteroid dehydrogenase type XI localizes to human steroidogenic cells

ZL Chai, P Brereton, T Suzuki, H Sasano, V Obeyesekere, G Escher, R Saffery, P Fuller, C Enriquez, Z Krozowski

Endocrinology | ENDOCRINE SOC | Published : 2003


We searched expressed sequence tag databases with conserved domains of the short-chain alcohol dehydrogenase superfamily and identified another isoform of 17 beta-hydroxysteroid dehydrogenase, 17 beta HSDXI. This enzyme converts 5 alpha-androstane-3 alpha, 17 beta-diol to androsterone. The substrate has been implicated in supporting gestation and modulating gamma-aminobutyric acid receptor activity. 17 beta HSDXI is colinear with human retinal short-chain dehydrogenase/reductase retSDR2, a protein with no known biological activity (accession no. AAF06939). Of the proteins with known function, 17 beta HSDXI is most closely related to the retinol-metabolizing enzyme retSDR1, with which it has ..

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