Maternal nutritional history modulates the hepatic IGF-IGFBP axis in adult male rat offspring
Timothy Smith, Deborah M Sloboda, Richard Saffery, Eric Joo, Mark H Vickers
ENDOCRINE | SPRINGER | Published : 2014
Alterations in early life nutrition lead to an increased risk of obesity and metabolic syndrome in offspring. We have shown that both relative maternal undernutrition (UN) and maternal obesity result in metabolic derangements in offspring, independent of the postnatal dietary environment. Since insulin-like growth factor binding protein 2 (IGFBP2) has been shown to be independently associated with obesity and diabetes risk, we examined the IGF-IGFBP axis in male rat offspring following either maternal UN or maternal obesity to explain possible common pathways in the development of metabolic disorders. Wistar rats were time-mated and fed either a control diet (CONT), 50 % of CONT (UN) or a hi..View full abstract
The authors thank Eric Thorstensen and Rachna Patel for performing the autoanalyser and ELISA assay analysis, respectively. We also acknowledge funding support from the Health Research Council of New Zealand and Gravida; the National Centre for Growth and Development, Auckland, New Zealand.