Journal article
Robust Gene Dysregulation in Alzheimer's Disease Brains
Xuemei Feng, Zhouxian Bai, Jiajia Wang, Bin Xie, Jiya Sun, Guangchun Han, Fuhai Song, Peter J Crack, Yong Duan, Hongxing Lei
JOURNAL OF ALZHEIMERS DISEASE | IOS PRESS | Published : 2014
DOI: 10.3233/JAD-140147
Abstract
The brain transcriptome of Alzheimer's disease (AD) reflects the prevailing disease mechanism at the gene expression level. However, thousands of genes have been reported to be dysregulated in AD brains in existing studies, and the consistency or discrepancy among these studies has not been thoroughly examined. Toward this end, we conducted a comprehensive survey of the brain transcriptome datasets for AD and other neurological diseases. We first demonstrated that the frequency of observed dysregulation in AD was highly correlated with the reproducibility of the dysregulation. Based on this observation, we selected 100 genes with the highest frequency of dysregulation to illustrate the core ..
View full abstractGrants
Awarded by NIGMS NIH HHS