The A9 dopamine neuron component in grafts of ventral mesencephalon is an important determinant for recovery of motor function in a rat model of Parkinson's disease
Shane Grealish, Marie E Jonsson, Meng Li, Deniz Kirik, Anders Bjorklund, Lachlan H Thompson
Brain: a journal of neurology | OXFORD UNIV PRESS | Published : 2010
Grafts of foetal ventral mesencephalon, used in cell replacement therapy for Parkinson's disease, are known to contain a mix of dopamine neuronal subtypes including the A9 neurons of the substantia nigra and the A10 neurons of the ventral tegmental area. However, the relative importance of these subtypes for functional repair of the brain affected by Parkinson's disease has not been studied thoroughly. Here, we report results from a series of grafting experiments where the anatomical and functional properties of grafts either selectively lacking in A9 neurons, or with a typical A9/A10 composition were compared. The results show that the A9 component of intrastriatal grafts is of critical imp..View full abstract
Awarded by Swedish Research Council
Awarded by European Union
The Swedish Research Council (04X-3874) and the Knut and Alice Wallenberg Foundation. L.T. was supported by funding from the NeuroNE Network of Excellence program of the European Union (LSHM-CT-2004-512039) and the National Parkinson Foundation (USA) Individual-Investigator grants program.