Lack of Insertional-Deletional Polymorphism in a Collection of Mycobacterium ulcerans Isolates from Ghanaian Buruli Ulcer Patients
Michael Kaeser, Oliver Gutmann, Julia Hauser, Tim Stinear, Stewart Cole, Dorothy Yeboah-Manu, Gregor Dernick, Ulrich Certa, Gerd Pluschke
Journal of Clinical Microbiology | AMER SOC MICROBIOLOGY | Published : 2009
Mycobacterium ulcerans causes the devastating infectious skin disease Buruli ulcer and has a monomorphic population structure. The resolution of conventional genetic fingerprinting methods is therefore not sufficient for microepidemiological studies aiming to characterize transmission pathways. In a previous comparative genomic hybridization analysis with a microarray covering part of the M. ulcerans genome, we have found extensive insertional-deletional sequence polymorphisms among M. ulcerans isolates of diverse geographic origins that allowed us to distinguish between strains coming from different continents. Since large numbers of insertion sequences are spread over the genome of African..View full abstract
This research activity was part of the Stop Buruli initiative funded by the UBS Optimus Foundation, Switzerland.