Bismuth(III) β-thioxoketonates as antibiotics against Helicobacter pylori and as anti-leishmanial agents

Abstract

Nine different β-thioxoketones of general formula R 1C(O)CH2C(S)R2 (R1 = C 6H5, R2 = C6H5L1; R 1 = C6H5, R2 = p-CF 3C6H4L2; R1 = p-MeOC 6H4, R2 = C6H5L3; R 1 = p-MeOC6H4, R2 = p-CF 3C6H4L4; R1 = C5H 4N, R2 = C6H5L5; R1 = p-IC6H4, R2 = C6H5L6; R1 = C6H5, R2 = p-IC 6H4L7; R1 = C6H5, R 2 = C10H7L8 and R1 = CH3, R2 = C6H5L9) and their tris-substituted bismuth(III) complexes having the general formula [Bi{R1C(O)CHC(S) R2}3] were synthesised and fully characterised. The solid state structure of [Bi{C5H4NC(O)CHC(S)C6H 5}3] B5 was determined by crystallography and revealed that the three β-thioxoketonato ligands are bound to bismuth(III) centre in a bidentate fashion through O and S atoms. The bismu..