Comparing dose prediction software used to manage gentamicin dosing

Abstract

Background: Current Australian guidelines recommend initiating directed therapy of gentamicin if administration exceeds 48h. Directed doses of gentamicin require the monitoring of plasma concentrations of gentamicin to determine the 24-h area under the time course of plasma gentamicin concentrations (AUC) and a dosage prediction program, for example TCIWorks or Aladdin. However, doses calculated by such programs have not been compared with an established program. Aim: To compare the directed dosage of gentamicin calculated by TCIWorks, Aladdin and an Excel-based program, with an established program, Abbottbase. Methods: Peak and trough plasma concentrations after the first and second adminis..