Effects of caffeine on renal and pulmonary function in preterm newborn lambs
Kelly J Crossley, Beth J Allison, Graeme R Polglase, Colin J Morley, Richard Harding, Peter G Davis, Timothy JM Moss, Stuart B Hooper
PEDIATRIC RESEARCH | NATURE PUBLISHING GROUP | Published : 2012
INTRODUCTION: Caffeine administration is associated with a reduction in bronchopulmonary dysplasia, assisted ventilation, patent ductus arteriosus (DA) and cerebral palsy in preterm infants, but the mechanisms are unknown. Our aim was to determine the effects of acute caffeine administration on renal and pulmonary function in preterm lambs. METHODS: Lambs were delivered by caesarean section at ~126 days of gestation and ventilated with a tidal volume of 5 ml/kg, 60 breaths/min and 5 cmH(2)O positive end-expiratory pressure. After 30 minutes, lambs received 40 mg/kg caffeine i.v (n=7) or saline (controls; n=6) over 30 minutes and were ventilated for 2 hours. RESULTS: Arterial caffeine concent..View full abstract
Awarded by National Health and Medical Research Council, Australia
This study was supported by the National Health and Medical Research Council, Australia (Grant 384100), and the Victorian government's Operational Infrastructure Support Program.