Surfactant Increases the Uniformity of Lung Aeration at Birth in Ventilated Preterm Rabbits
Melissa L Siew, Arjan B Te Pas, Megan J Wallace, Marcus J Kitchen, M Sirajul Islam, Robert A Lewis, Andreas Fouras, Colin J Morley, Peter G Davis, Naoto Yagi, Kentaro Uesugi, Stuart B Hooper
Pediatric Research | INT PEDIATRIC RESEARCH FOUNDATION, INC | Published : 2011
Surfactant deficiency is a major cause of respiratory failure in newborns. We have investigated the roles of surfactant and positive end-expiratory pressure (PEEP) in the development of a functional residual capacity (FRC) and the distribution of ventilation at birth. Preterm rabbit pups (28 d GA) were delivered and received either saline or surfactant and then ventilated with (3PEEP) or without (0PEEP) 3 cm H2O PEEP (groups: saline/0PEEP, surfactant/0PEEP, saline/3PEEP, surfactant/3PEEP). Lung gas volumes were measured using plethysmography, and the uniformity of ventilation was analyzed using phase contrast (PC) x-ray imaging. Surfactant/0PEEP pups had greater FRCs and the lungs were more ..View full abstract
Supported by the Australian Research Council and the Australian National Health and Medical Research Council. Financial support from the Access to Major Research Facilities Programme was provided by the Australian Government.