Journal article

Surfactant Increases the Uniformity of Lung Aeration at Birth in Ventilated Preterm Rabbits

Melissa L Siew, Arjan B Te Pas, Megan J Wallace, Marcus J Kitchen, M Sirajul Islam, Robert A Lewis, Andreas Fouras, Colin J Morley, Peter G Davis, Naoto Yagi, Kentaro Uesugi, Stuart B Hooper

Pediatric Research | INT PEDIATRIC RESEARCH FOUNDATION, INC | Published : 2011


Surfactant deficiency is a major cause of respiratory failure in newborns. We have investigated the roles of surfactant and positive end-expiratory pressure (PEEP) in the development of a functional residual capacity (FRC) and the distribution of ventilation at birth. Preterm rabbit pups (28 d GA) were delivered and received either saline or surfactant and then ventilated with (3PEEP) or without (0PEEP) 3 cm H2O PEEP (groups: saline/0PEEP, surfactant/0PEEP, saline/3PEEP, surfactant/3PEEP). Lung gas volumes were measured using plethysmography, and the uniformity of ventilation was analyzed using phase contrast (PC) x-ray imaging. Surfactant/0PEEP pups had greater FRCs and the lungs were more ..

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