Journal article

A comparative study of the action of dexamethasone sodium phosphate and dexamethasone acetate in steroid-eluting pacemaker leads

S Singarayar, PM Kistler, C De Winter, H Mond

PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY | WILEY | Published : 2005

Abstract

BACKGROUND: The aim of this study was to characterize acute and medium-term pacemaker lead performance with the two most commonly used glucocorticosteroids: dexamethasone sodium phosphate and dexamethasone acetate. METHODS: Forty sets of atrial and ventricular passive-fixation leads containing either dexamethasone sodium phosphate or dexamethasone acetate were implanted as dual chamber pacemakers. Randomization was equally distributed to both arms of the study. Stimulation thresholds, lead impedance, and sensing were measured on the day of implant, day 1, 1 month, 3 months, and 6 months following the implant. RESULTS: For the dexamethasone sodium phosphate arm, the atrial stimulation thresho..

View full abstract