Myocardial Fibrosis Predicts Appropriate Device Therapy in Patients With Implantable Cardioverter-Defibrillators for Primary Prevention of Sudden Cardiac Death
Leah Iles, Heinz Pfluger, Lisa Lefkovits, Michelle J Butler, Peter M Kistler, David M Kaye, Andrew J Taylor
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY | ELSEVIER SCIENCE INC | Published : 2011
OBJECTIVES: The purpose of this study was to evaluate the association between regional myocardial fibrosis and ventricular arrhythmias in patients with cardiomyopathy. BACKGROUND: Patients with heart failure are at risk of sudden cardiac death (SCD). Current guidelines recommend implantable cardioverter-defibrillator (ICD) devices for a subgroup based on impaired left ventricular function. A significant proportion of devices never discharge, hence a more accurate method for targeting those at risk is desirable. METHODS: We prospectively enrolled 103 patients meeting criteria for ICD implantation for primary prevention of SCD. Cardiac magnetic resonance imaging was performed before device imp..View full abstract
Dr. Iles is supported by a National Health and Medical Research Council Post Graduate Research Scholarship, Melbourne, Australia. Dr. Pfluger is supported by a research grant from Swiss National Science Foundation SNSF, Bern, Switzerland. Dr. Butler is supported by an Australian Post-Graduate Award, Monash University, Melbourne, Australia. Dr. Kistler is the recipient of a research investigatorship from the Cardiac Society of Australasia. Dr. Taylor is supported by a National Health and Medical Research Council program grant, and an Australian National Heart Foundation project grant. All other authors have reported that they have no relationships to disclose.