Journal article

Genetic diversity of VAR2CSA ID1-DBL2Xb in worldwide Plasmodium falciparum populations: Impact on vaccine design for placental malaria

Bita Bordbar, Nicaise Tuikue Ndam, Emmanuelle Renard, Sayeh Jafari-Guemouri, Livingstone Tavul, Charlie Jennison, Sedami Gnidehou, Rachida Tahar, Dionicia Gamboa, Jorge Bendezu, Didier Menard, Alyssa E Barry, Philippe Deloron, Audrey Sabbagh

Infection Genetics and Evolution | ELSEVIER SCIENCE BV | Published : 2014


In placental malaria (PM), sequestration of infected erythrocytes in the placenta is mediated by an interaction between VAR2CSA, a Plasmodium falciparum protein expressed on erythrocytes, and chondroitin sulfate A (CSA) on syncytiotrophoblasts. Recent works have identified ID1-DBL2Xb as the minimal CSA-binding region within VAR2CSA able to induce strong protective immunity, making it the leading candidate for the development of a vaccine against PM. Assessing the existence of population differences in the distribution of ID1-DBL2Xb polymorphisms is of paramount importance to determine whether geographic diversity must be considered when designing a candidate vaccine based on this fragment. I..

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Awarded by "Investissements d'avenir'' - Laboratory of excellence GREx

Awarded by European 7th Framework Programme

Awarded by French National Agency of Research

Awarded by National Health and Medical Research Council of Australia Project

Funding Acknowledgements

We are grateful to all subjects who participated in the study. We also thank Jerome Clain for helpful discussions. UMR216 is supported by the ''Investissements d'avenir'' funded Laboratory of excellence GREx. Samples from Benin were collected in the context of the STOPPAM (Strategies TO Prevent Pregnancy Associated Malaria) project. STOPPAM is a Small & Medium Scale Collaborative Project supported by the European 7th Framework Programme, contract number: 200889. Samples from Senegal were collected with the funding from the French National Agency of Research (Grant # ANR-05-MIME-009-01). The Papua New Guinea (PNG) samples were collected by N. Senn, I. Mueller and colleagues at the PNG Institute of Medical Research with support from a grant from the Bill and Melinda Gates Foundation. Molecular work on PNG samples was supported by the National Health and Medical Research Council of Australia Project Grant No. 1005653 and the Victorian State Government Operational Infrastructure Support and Australian Government NHMRC IRIISS.