Elevated PGC-1 alpha Activity Sustains Mitochondrial Biogenesis and Muscle Function without Extending Survival in a Mouse Model of Inherited ALS
Sandrine Da Cruz, Philippe A Parone, Vanda S Lopes, Concepcion Lillo, Melissa McAlonis-Downes, Sandra K Lee, Anne P Vetto, Susanna Petrosyan, Martin Marsala, Anne N Murphy, David S Williams, Bruce M Spiegelman, Don W Cleveland
Cell Metabolism | CELL PRESS | Published : 2012
Awarded by NATIONAL EYE INSTITUTE
Awarded by NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
We are very grateful to Prof. Randal Johnson for the use his treadmill apparatus. This work has been supported by grants from the Muscular Dystrophy Association and the NIH to D.W.C. S.D.C. was supported by a postdoctoral fellowship from the ALS Association. Salary support for D.W.C. is provided by the Ludwig Institute for Cancer Research. Support from the NIH and an RPB Jules and Doris Stein Professorship was also provided to D.S.W.