Journal article

Prevention of Nonimmunologic Loss of Transplanted Islets in Monkeys

M Koulmanda, RS Sampathkumar, M Bhasin, A Qipo, Z Fan, G Singh, B Movahedi, M Duggan, V Chipashvili, TB Strom

AMERICAN JOURNAL OF TRANSPLANTATION | WILEY | Published : 2014

Abstract

The nonimmunologic loss of islets in the pre-, peri-, and early post-islet transplant periods is profound. To determine the potential role that transplantation of only a marginal mass of functioning beta cells may play in triggering late nonimmunologic graft loss, we studied the effect of treatment with alpha-1-antitrypsin (AAT) in the autologous cynomolgus islet transplant model. A marginal mass of autologous islets, that is islets prepared from 70% to 80% of the pancreas, was transplanted at 1600-4100 IEQ/kg into subtotal pancreatectomized, streptozotocin-treated and insulin-deficient diabetic hosts. In this marginal mass islet transplant model, islet function is insidiously lost over time..

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University of Melbourne Researchers

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Awarded by NIH


Awarded by JDRF


Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES


Awarded by NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES


Funding Acknowledgements

We thank Neal R. Smith, from the Massachusetts General Hospital, for his expert pathologic studies. This work was funded in part by NIH 5 RO1 AI50987, NIH 1-U19 DK080652, JDRF 7-2005-1329 (TBS and MK) and a JDRF postdoctoral fellowship grant (MB).