Journal article

Role of myeloid-derived suppressor cells in mouse pre-sensitized cardiac transplant model

Weihua Gong, Fangmin Ge, Dahai Liu, Yan Wu, Fangbing Liu, Beom Seok Kim, Tao Huang, Maria Koulmanda, Simon C Robson, Terry B Strom

CLINICAL IMMUNOLOGY | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2014

Abstract

Harness of sensitized transplantation remains a clinical challenge particularly in parallel with prolonged cold ischemia time (PCI)-mediated injury. Our present study was to test the role of myeloid-derived suppressor cells (MDSCs) in mouse pre-sensitized transplantation. Our findings revealed that CD11b+Gr1(low) MDSC was shown to have strong suppressive activity. MDSCs subsets from the tolerated mice exhibited higher suppressive capacities compared with counterparts from naive (untreated) mice. Depletion of Tregs could not affect splenic CD11b+Gr1(-low) MDSC frequency, but increase peripheral and intragraft CD11b+Gr1(-low) frequency. Intriguingly, boost of Tregs remarkably caused an increas..

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University of Melbourne Researchers

Grants

Awarded by Department of Education of Zhejiang Province


Awarded by National Natural Science Foundation of China


Awarded by Qianjiang Talents Project of Zhejiang Province


Awarded by Zhejiang Provincial Outstanding Youth Foundation


Funding Acknowledgements

The work was supported by the Department of Education of Zhejiang Province (Grant No. Y201226017), the National Natural Science Foundation of China (No. 81270323), the Qianjiang Talents Project of Zhejiang Province (Grant No.2012R10022), and the Zhejiang Provincial Outstanding Youth Foundation (Grant No. LR13H020001).