Journal article

Concepts and controversies of juvenile myoclonic epilepsy: still an enigmatic epilepsy

Matthias J Koepp, Rhys H Thomas, Britta Wandschneider, Samuel F Berkovic, Dieter Schmidt

Expert Review of Neurotherapeutics | TAYLOR & FRANCIS LTD | Published : 2014

Abstract

Juvenile myoclonic epilepsy (JME) is a clinically and genetically heterogenous, generalized epilepsy syndrome usually starting in adolescence. An age-related, predominantly frontocortical-subcortical network dysfunction is likely to be the substrate of bilateral myoclonic seizures occurring at full consciousness within hours after awakening, which are the clinical hallmark of JME. Although essential features of JME were recognized by Herpin more than 140 years ago, it is still an enigmatic epilepsy syndrome in many ways; advanced imaging techniques reveal multi-focal abnormalities in this paradigmatic generalized epilepsy syndrome; clinical studies reveal a major role of genetics in etiology..

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University of Melbourne Researchers