Journal article

New insights into how HBV manipulates the innate immune response to establish acute and persistent infection

Peter Revill, Zhenghong Yuan

Antiviral Therapy | INT MEDICAL PRESS LTD | Published : 2013

Abstract

The mechanisms by which HBV establishes and maintains chronic infection are poorly understood. Although adult acquired HBV is generally cleared by a robust immune response, most individuals infected at childbirth or in very early childhood develop lifelong chronic infection. In addition, acute infections are unresolved in approximately 5% of individuals infected in adulthood. The host cell mechanisms that ensure establishment and resolution of acute infection and persistent infection remain unclear. Currently, two schools of thought suggest that either HBV is a 'stealth' virus, which initially establishes infection by avoiding host innate immune responses, or that HBV facilitates initial inf..

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University of Melbourne Researchers