Axonal loss of retinal neurons in multiple sclerosis associated with optic radiation lesions
Alexander Klistorner, Prima Sriram, Nikitha Vootakuru, Chenyu Wang, Michael H Barnett, Raymond Garrick, John Parratt, Netta Levin, Noa Raz, Anneke Van der Walt, Lynette Masters, Stuart L Graham, Con Yiannikas
Neurology | LIPPINCOTT WILLIAMS & WILKINS | Published : 2014
OBJECTIVE: To investigate the potential links between thinning of retinal ganglion cell axons in eyes of patients with multiple sclerosis (MS) without past optic neuritis (ON) and MS-related inflammatory damage of the posterior visual pathway. METHODS: Temporal retinal nerve fiber layer (tRNFL) thickness was analyzed in eyes with no history of ON (NON) from 53 patients with relapsing-remitting MS. Fifty normal age- and sex-matched controls were examined with optical coherence tomography. Low-contrast visual acuity charts were used for functional assessment of vision. The optic tract (OT) and optic radiation (OR) were identified using probabilistic tractography, and volume of T2 fluid-attenua..View full abstract
Awarded by Sydney Medical Foundation
Supported by Save Neuron grants from Novartis, Sydney Medical Foundation (grant number E34), and Sydney Hospital Foundation.