Journal article

Case-case-control study on factors associated with vanB vancomycin-resistant and vancomycin-susceptible enterococcal bacteraemia

Agnes Loo Yee Cheah, Trisha Peel, Benjamin P Howden, Denis Spelman, M Lindsay Grayson, Roger L Nation, David CM Kong



BACKGROUND: Enterococci are a major cause of healthcare-associated infection. In Australia, vanB vancomycin-resistant enterococci (VRE) is the predominant genotype. There are limited data on the factors linked to vanB VRE bacteraemia. This study aimed to identify factors associated with vanB VRE bacteraemia, and compare them with those for vancomycin-susceptible enterococci (VSE) bacteraemia. METHODS: A case-case-control study was performed in two tertiary public hospitals in Victoria, Australia. VRE and VSE bacteraemia cases were compared with controls without evidence of enterococcal bacteraemia, but may have had infections due to other pathogens. RESULTS: All VRE isolates had vanB genotyp..

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Funding Acknowledgements

DCMK has sat on advisory board for Merck, Sharp & Dohme, and Pfizer. He receives financial support (not related to the current work) from Pfizer, Novartis, Merck and Gilead Sciences. All other authors: No relevant disclosures.