Functional beta-Adrenoceptors Are Important for Early Muscle Regeneration in Mice through Effects on Myoblast Proliferation and Differentiation
Jarrod E Church, Jennifer Trieu, Radhika Sheorey, Annabel Y-M Chee, Timur Naim, Dale M Baum, James G Ryall, Paul Gregorevic, Gordon S Lynch
PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2014
Muscles can be injured in different ways and the trauma and subsequent loss of function and physical capacity can impact significantly on the lives of patients through physical impairments and compromised quality of life. The relative success of muscle repair after injury will largely determine the extent of functional recovery. Unfortunately, regenerative processes are often slow and incomplete, and so developing novel strategies to enhance muscle regeneration is important. While the capacity to enhance muscle repair by stimulating β2-adrenoceptors (β-ARs) using β2-AR agonists (β2-agonists) has been demonstrated previously, the exact role β-ARs play in regulating the regenerative process re..View full abstract
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Awarded by National Health and Medical Research Council (NHMRC) of Australia
This work was supported by the National Health and Medical Research Council (NHMRC) of Australia (Project grants: 509313; 1026231). JEC was supported by a postdoctoral fellowship from the Association Francaise contre les Myopathies (AFM, France). PG was supported by a NHMRC Career Development Fellowship and formerly a Pfizer Senior Research Fellowship. JGR is supported by a NHMRC Overseas Postdoctoral Fellowship. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.