A marker-derived gene network reveals the regulatory role of PPARGC1A, HNF4G, and FOXP3 in intramuscular fat deposition of beef cattle
Y Ramayo-Caldas, MRS Fortes, NJ Hudson, LR Porto-Neto, S Bolormaa, W Barendse, M Kelly, SS Moore, ME Goddard, SA Lehnert, A Reverter
Journal of Animal Science | OXFORD UNIV PRESS INC | Published : 2014
High intramuscular fat (IMF) awards price premiums to beef producers and is associated with meat quality and flavor. Studying gene interactions and pathways that affect IMF might unveil causative physiological mechanisms and inform genomic selection, leading to increased accuracy of predictions of breeding value. To study gene interactions and pathways, a gene network was derived from genetic markers associated with direct measures of IMF, other fat phenotypes, feedlot performance, and a number of meat quality traits relating to body conformation, development, and metabolism that might be plausibly expected to interact with IMF biology. Marker associations were inferred from genomewide assoc..View full abstract
Awarded by Spanish Ministerio de Educacion
Awarded by European Union
The authors acknowledge the Cooperative Research Centre for Beef Genetic Technologies for provision of individual cattle genotyping data. Y. Ramayo-Caldas was funded by an FPU PhD scholarship from the Spanish Ministerio de Educacion (AP2008-01450) and has received the support of the European Union, in the framework of the Marie-Curie FP7 COFUND People Programme, through the award of an AgreenSkills' fellowship (under grant agreement number 267196).