Effect of Platinum-Based Chemoradiotherapy on Cellular Proliferation in Bone Marrow and Spleen, Estimated by F-18-FLT PET/CT in Patients with Locally Advanced Non-Small Cell Lung Cancer
Antoine Leimgruber, Andreas Moeller, Sarah J Everitt, Marine Chabrot, David L Ball, Ben Solomon, Michael MacManus, Rodney J Hicks
JOURNAL OF NUCLEAR MEDICINE | SOC NUCLEAR MEDICINE INC | Published : 2014
UNLABELLED: Historically, it has been difficult to monitor the acute impact of anticancer therapies on hematopoietic organs on a whole-body scale. Deeper understanding of the effect of treatments on bone marrow would be of great potential value in the rational design of intensive treatment regimens. 3'-deoxy-3'-(18)F-fluorothymidine ((18)F-FLT) is a functional radiotracer used to study cellular proliferation. It is trapped in cells in proportion to thymidine-kinase 1 enzyme expression, which is upregulated during DNA synthesis. This study investigates the potential of (18)F-FLT to monitor acute effects of chemotherapy on cellular proliferation and its recovery in bone marrow, spleen, and liv..View full abstract
Awarded by NHMRC
The costs of publication of this article were defrayed in part by the payment of page charges. Therefore, and solely to indicate this fact, this article is hereby marked "advertisement" in accordance with 18 USC section 1734. This study is supported by the SICPA Foundation, The CASS Foundation, and NHMRC grant APP1003895. No other potential conflict of interest relevant to this article was reported.