Journal article

Effect of Platinum-Based Chemoradiotherapy on Cellular Proliferation in Bone Marrow and Spleen, Estimated by F-18-FLT PET/CT in Patients with Locally Advanced Non-Small Cell Lung Cancer

Antoine Leimgruber, Andreas Moeller, Sarah J Everitt, Marine Chabrot, David L Ball, Ben Solomon, Michael MacManus, Rodney J Hicks

Journal of Nuclear Medicine | SOC NUCLEAR MEDICINE INC | Published : 2014

Abstract

UNLABELLED: Historically, it has been difficult to monitor the acute impact of anticancer therapies on hematopoietic organs on a whole-body scale. Deeper understanding of the effect of treatments on bone marrow would be of great potential value in the rational design of intensive treatment regimens. 3'-deoxy-3'-(18)F-fluorothymidine ((18)F-FLT) is a functional radiotracer used to study cellular proliferation. It is trapped in cells in proportion to thymidine-kinase 1 enzyme expression, which is upregulated during DNA synthesis. This study investigates the potential of (18)F-FLT to monitor acute effects of chemotherapy on cellular proliferation and its recovery in bone marrow, spleen, and liv..

View full abstract