Journal article

Differential F-18-FDG and F-18-FLT Uptake on Serial PET/CT Imaging Before and During Definitive Chemoradiation for Non-Small Cell Lung Cancer

Sarah J Everitt, David L Ball, Rodney J Hicks, Jason Callahan, Nikki Plumridge, Marnie Collins, Alan Herschtal, David Binns, Tomas Kron, Michal Schneider, Michael MacManus

Journal of Nuclear Medicine | SOC NUCLEAR MEDICINE INC | Published : 2014

Abstract

UNLABELLED: We aimed to prospectively observe cellular metabolism and proliferation in patients with non-small-cell lung cancer (NSCLC) during radical chemoradiation therapy using serial PET/CT with (18)F-FDG and 3'-deoxy-3'-(18)F-fluorothymidine ((18)F-FLT). METHODS: Twenty patients with stage I-III NSCLC and candidates for radical chemoradiation therapy (60 Gy in 30 fractions over 6 wk) were recruited. (18)F-FDG and (18)F-FLT PET/CT were performed at baseline and during therapy (weeks 2 and 4). Tumor response was assessed semiquantitatively and using visual response criteria. RESULTS: The median and range for primary tumor volume (cm(3)) at baseline on (18)F-FDG were 28 and 2-241, respecti..

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