Differential F-18-FDG and F-18-FLT Uptake on Serial PET/CT Imaging Before and During Definitive Chemoradiation for Non-Small Cell Lung Cancer
Sarah J Everitt, David L Ball, Rodney J Hicks, Jason Callahan, Nikki Plumridge, Marnie Collins, Alan Herschtal, David Binns, Tomas Kron, Michal Schneider, Michael MacManus
Journal of Nuclear Medicine | SOC NUCLEAR MEDICINE INC | Published : 2014
UNLABELLED: We aimed to prospectively observe cellular metabolism and proliferation in patients with non-small-cell lung cancer (NSCLC) during radical chemoradiation therapy using serial PET/CT with (18)F-FDG and 3'-deoxy-3'-(18)F-fluorothymidine ((18)F-FLT). METHODS: Twenty patients with stage I-III NSCLC and candidates for radical chemoradiation therapy (60 Gy in 30 fractions over 6 wk) were recruited. (18)F-FDG and (18)F-FLT PET/CT were performed at baseline and during therapy (weeks 2 and 4). Tumor response was assessed semiquantitatively and using visual response criteria. RESULTS: The median and range for primary tumor volume (cm(3)) at baseline on (18)F-FDG were 28 and 2-241, respecti..View full abstract
Awarded by National Health and Medical Research Council
The costs of publication of this article were defrayed in part by the payment of page charges. Therefore, and solely to indicate this fact, this article is hereby marked "advertisement" in accordance with 18 USC section 1734. This work is supported by a National Health and Medical Research Council project grant (APP1003895) and Victorian Cancer Agency Tumor Stream Research grant. No other potential conflict of interest relevant to this article was reported.