Journal article

Corticosterone treatment during adolescence induces down-regulation of reelin and NMDA receptor subunit GLUN2C expression only in male mice: implications for schizophrenia

Laetitia Buret, Maarten van den Buuse

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY | OXFORD UNIV PRESS | Published : 2014

Abstract

Stress exposure during adolescence/early adulthood has been shown to increase the risk for psychiatric disorders such as schizophrenia. Reelin plays an essential role in brain development and its levels are decreased in schizophrenia. However, the relationship between stress exposure and reelin expression remains unclear. We therefore treated adolescent reelin heteroyzogous mice (HRM) and wild-type (WT) littermates with the stress hormone, corticosterone (CORT) in their drinking water (25 mg/l) for 3 wk. In adulthood, we measured levels of full-length (FL) reelin and the N-R6 and N-R2 cleavage fragments in the frontal cortex (FC) and dorsal (DH) and ventral (VH) hippocampus. As expected, lev..

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Grants

Awarded by National Health and Medical Research Council of Australia (NHMRC)


Funding Acknowledgements

These studies were supported by a project grant (APP1004129) and a Senior Research Fellowship (to MvdB, ID-509156) from the National Health and Medical Research Council of Australia (NHMRC) and by Operational Infrastructure Funding from the Victorian State Government. The authors are grateful to Ms Sally Martin and Dr Anand Gururajan for assistance with mouse breeding and genotyping.