Journal article
Distinct patterns of diversity, population structure and evolution in the AMA1 genes of sympatric Plasmodium falciparum and Plasmodium vivax populations of Papua New Guinea from an area of similarly high transmission
A Arnott, J Wapling, I Mueller, PA Ramsland, PM Siba, JC Reeder, AE Barry
Malaria Journal | Published : 2014
Abstract
Background: As Plasmodium falciparum and Plasmodium vivax co-exist in most malaria-endemic regions outside sub-Saharan Africa, malaria control strategies in these areas must target both species in order to succeed. Population genetic analyses can predict the effectiveness of interventions including vaccines, by providing insight into patterns of diversity and evolution. The aim of this study was to investigate the population genetics of leading malaria vaccine candidate AMA1 in sympatric P. falciparum and P. vivax populations of Papua New Guinea (PNG), an area of similarly high prevalence (Pf = 22.3 to 38.8%, Pv = 15.3 to 31.8%). Methods. A total of 72 Pfama1 and 102 Pvama1 sequences were co..
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Awarded by Burnet Institute
Funding Acknowledgements
The research was supported by Project Grants 488221 and 1003825 from the National Health and Medical Research Council of Australia (NHMRC). Samples were collected as part of a Bill and Melinda Gates Foundation funded project. IM is a Senior Research Fellow of the NHMRC. This work was made possible through Victorian State Government Operational Infrastructure Support and Australian Government NHMRC IRIISS received by the Burnet Institute and the Walter and Eliza Hall Institute.