Drugs currently in Phase II clinical trials for cocaine addiction
Jee Hyun Kim, Andrew J Lawrence
Expert Opinion on Investigational Drugs | TAYLOR & FRANCIS LTD | Published : 2014
INTRODUCTION: There are no FDA-approved pharmacotherapies for treating cocaine addiction; thus, developing drugs to treat cocaine dependence is an unmet critical need. Fortunately, there are a number of drugs that are currently in Phase II clinical trial/s. This is due in part to the advances from in vivo imaging in humans which provided a roadmap of the neurochemistry of the cocaine-dependent brain. Most drugs currently in Phase II clinical trials attempt to modulate the disturbed neurochemistry in cocaine dependents to resemble those of healthy individuals. These predominantly modulate dopamine, serotonin, glutamate, GABA or noradrenaline signalling. AREAS COVERED: This review summarizes t..View full abstract
AJ Lawrence is a Principal Research Fellow of the National Health and Medical Research Council (NHMRC) of Australia. JH Kim is an Australian Research Council DECRA Fellow. The authors also acknowledge support from the Victorian Government's Operational Infrastructure Support Program. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.