Mesoporous Silica Supraparticles for Sustained Inner-Ear Drug Delivery

Y Wang; JW Maina; F Caruso; AK Wise; RK Shepherd; J Tan

Journal article

Mesoporous Silica Supraparticles for Sustained Inner-Ear Drug Delivery

Y Wang, JW Maina, F Caruso, AK Wise, RK Shepherd, J Tan

Small | Wiley | Published : 2014

DOI: 10.1002/smll.201401767

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Abstract

Mesoporous silica supraparticles (MS-SPs) are prepared via self-assembly of mesoporous silica nanoparticles under capillary force action in confined droplets. The MS-SPs are effective carriers for sustained drug delivery. Animal studies show that these particles are suitable for chronic intracochlear implantation, and neurotrophins released from the MS-SPs can efficiently rescue primary auditory neurons in an in vivo sensorineural hearing loss model.

University of Melbourne Researchers

Robert Shepherd Author Medical Bionics Department

Justin Tan Author Otolaryngology

Andrew Wise Author Medical Bionics Department

Frank Caruso Author Chemical Engineering

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Grants

Awarded by National Health and Medical Research Council (NHMRC)

Awarded by Australian Research Council under the Australian Laureate Fellowship scheme

Awarded by National Institutes of Health (USA)

Awarded by National Natural Science Foundation of China

Funding Acknowledgements

Y.W. and A.K.W. contributed equally to this work. This work was supported by the National Health and Medical Research Council (NHMRC) Project Grant APP1005071 (R.K.S., F.C., J.T., Y.W., A.K.W) and Project Grant APP1064375 (A.K.W., F.C. and R.K.S.), by the Australian Research Council under the Australian Laureate Fellowship scheme (F.C., 120100030) and the National Institutes of Health (USA) HHS-N-263-2007-00053-C (R.K.S.). The Bionics Institute acknowledges the support it receives from the Victorian government through its Operational Infrastructure Support Program. Y.W. acknowledges support from The National Young 1000 Talents Program of China and the National Natural Science Foundation of China (21373059).