Journal article

Identification of susceptibility loci for colorectal cancer in a genome-wide meta-analysis

Nicola Whiffin, Fay J Hosking, Susan M Farrington, Claire Palles, Sara E Dobbins, Lina Zgaga, Amy Lloyd, Ben Kinnersley, Maggie Gorman, Albert Tenesa, Peter Broderick, Yufei Wang, Ella Barclay, Caroline Hayward, Lynn Martin, Daniel D Buchanan, Aung Ko Win, John Hopper, Mark Jenkins, Noralane M Lindor Show all

HUMAN MOLECULAR GENETICS | OXFORD UNIV PRESS | Published : 2014

Grants

Awarded by Cancer Research UK


Awarded by European Union


Awarded by COST Action


Awarded by Scottish Government Health Department, Chief Scientist Office


Awarded by Wellcome Trust Centre for Human Genetics, Oxford


Awarded by National Cancer Institute, National Institutes of Health under RFA


Awarded by National Cancer Institute, National Institutes of Health


Awarded by NATIONAL CANCER INSTITUTE


Awarded by Medical Research Council


Awarded by Chief Scientist Office


Funding Acknowledgements

Cancer Research UK provided principal funding for this study to R.S.H., I.P.M.T. and M.G.D. In addition, this work was supported by the European Union (FP7/207-2013) under grant 258236, FP7 collaborative project SYSCOL and COST Action BM1206.At the Institute of Cancer Research, the work was supported by a Programme Grant from Cancer Research UK (C1298/A8362-Bobby Moore Fund for Cancer Research UK). Additional support was provided by the National Cancer Research Network and the NHS via the Biological Research Centre of the National Institute for Health Research at the Royal Marsden Hospital NHS Trust. N.W. and B.K. were in receipt of PhD studentships from the ICR. B.K. additionally receives funding from the Sir John Fisher Foundation.In Edinburgh the work was supported by Programme Grant funding from Cancer Research UK (C348/A12076). We are most grateful to all participants of the SOCCS/COGS studies and Generation Scotland, without whom our research could not be conducted. We acknowledge the excellent technical support from CCGG technicians and the COGS/SOCCS operational team: study coordinators, recruitment nurses, data entry and collation. Generation Scotland is a collaboration between the University Medical Schools and NHS in Aberdeen, Dundee, Edinburgh and Glasgow. The Generation Scotland Family Health Study (http://www.generationscotland.org) was funded by a grant from the Scottish Government Health Department, Chief Scientist Office, CZD/16/6. Genotyping was funded by the UK Medical Research Council. We are grateful to GPs and Scottish School of Primary Care for help with recruitment to GS:SFHS. We acknowledge the excellent work of the whole GS team: academic researchers, clinic staff, laboratory technicians, clerical workers, statisticians and research managers. We acknowledge the expert support on sample preparation and genotyping by the Genetics Core of the Edinburgh University Wellcome Trust Clinical Research Facility.In Oxford additional funding was provided by the Oxford Comprehensive Biomedical Research Centre (C.P. and I.P.M.T.) and the EU FP7 CHIBCHA grant (I.P. M.T.). Core infrastructure support to the Wellcome Trust Centre for Human Genetics, Oxford was provided by grant (090532/Z/09/Z). We are grateful to many colleagues within UK Clinical Genetics Departments (for CORGI) and to many collaborators who participated in the VICTOR and QUASAR2 trials. We also thank colleagues from the UK National Cancer Research Network (for NSCCG).The Swedish sample and data resource was funded by the Swedish Cancer Society, the Swedish Scientific Research Council and the Stockholm Cancer Foundation. We acknowledge the contribution to recruitment and data collection of the Swedish Low-Risk Colorectal Cancer Study Group.The work of the Colon Cancer Family Registry CFR was supported by the National Cancer Institute, National Institutes of Health under RFA #CA-95-011 and through cooperative agreements with members of the Colon CFR and Principal Investigators. Collaborating centres include the Australasian Colorectal Cancer Family Registry (U01 CA097735), the USC Familial Colorectal Neoplasia Collaborative Group (U01 CA074799), Mayo Clinic Cooperative Familial Registry for Colon Cancer Studies (U01 CA074800), Ontario Registry for Studies of Familial Colorectal Cancer (U01 CA074783) and the Seattle Colorectal Cancer Family Registry (U01 CA074794). The Colon CFR GWAS was supported by funding from the National Cancer Institute, National Institutes of Health (U01CA122839 to GC).